The significance of Lactobacillus crispatus and L. vaginalis for vaginal health and the negative effect of recent sex: a cross-sectional descriptive study across groups of African women. Authors:

نویسندگان

  • Vicky Jespers
  • Janneke van de Wijgert
  • Piet Cools
  • Rita Verhelst
  • Hans Verstraelen
  • Sinead Delany-Moretlwe
  • Gilles F Ndayisaba
  • Kishor Mandaliya
  • Joris Menten
  • Liselotte Hardy
  • Tania Crucitti
چکیده

1 Unit of Epidemiology and Control of HIV/STD, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium; 2 Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; 3 Laboratory Bacteriology Research, University Gent, Ghent, Belgium; 4 International Center for Reproductive Health (ICRH), Ghent University, Ghent, Belgium; 5 Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; 6 Wits Reproductive Health & HIV Institute, University of Witwatersrand, Johannesburg, South Africa; 7 ICRH Kenya, Mombasa, Kenya; 8 Rinda Ubuzima, Kigali, Rwanda; 9 Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; 10 HIV/STI Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

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The significance of Lactobacillus crispatus and L. vaginalis for vaginal health and the negative effect of recent sex: a cross-sectional descriptive study across groups of African women

BACKGROUND Women in sub-Saharan Africa are vulnerable to acquiring HIV infection and reproductive tract infections. Bacterial vaginosis (BV), a disruption of the vaginal microbiota, has been shown to be strongly associated with HIV infection. Risk factors related to potentially protective or harmful microbiota species are not known. METHODS We present cross-sectional quantitative polymerase c...

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Identification and characterisation of vaginal lactobacilli from South African women

BACKGROUND Bacterial vaginosis (BV), which is highly prevalent in the African population, is one of the most common vaginal syndromes affecting women in their reproductive age placing them at increased risk for sexually transmitted diseases including infection by human immunodeficiency virus-1. The vaginal microbiota of a healthy woman is often dominated by the species belonging to the genus La...

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Lactobacillus crispatus Dominant Vaginal Microbiome Is Associated with Inhibitory Activity of Female Genital Tract Secretions against Escherichia coli

OBJECTIVE Female genital tract secretions inhibit E. coli ex vivo and the activity may prevent colonization and provide a biomarker of a healthy microbiome. We hypothesized that high E. coli inhibitory activity would be associated with a Lactobacillus crispatus and/or jensenii dominant microbiome and differ from that of women with low inhibitory activity. STUDY DESIGN Vaginal swab cell pellet...

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Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity.

BACKGROUND To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods. METHODS Evaluation of indicators for BV was carrie...

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تاریخ انتشار 2014